Calcium, the most abundant mineral in the body, is important for bone health and several major physiologic functions (1). The use of calcium supplements to prevent osteoporotic fractures is widespread, and thus, any beneficial or adverse effects of calcium supplements on health is of great public health importance.
Recent clinical practice guidelines recommend to avoid “diabetes overtreatment” in older people living with type 2 diabetes (T2D), conceptually corresponding to an inappropriate level of glycemia that places the patient at high risk of unwanted side effects of glucose-lowering treatment (e.g., hypoglycemia), without providing a clinically implementable definition of this concept (1,2).